Modulation of GABAA receptor channel gating by pentobarbital
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منابع مشابه
Proton Modulation of 1 3 GABAA Receptor Channel Gating and Desensitization
Feng, Hua-Jun and Robert L. Macdonald. Proton modulation of 1 3 GABAA receptor channel gating and desensitization. J Neurophysiol 92: 1577–1585, 2004. First published May 19, 2004; 10.1152/jn.00285.2004. GABAA receptor currents are phasic and desensitizing, whereas GABAA receptor currents are tonic and have no fast desensitization. receptors are subsynaptic and mediate phasic inhibition, wherea...
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αβγ GABAA receptor currents are phasic and desensitizing while αβδ GABAA receptor currents are tonic and have no fast desensitization. αβγ receptors are subsynaptic and mediate phasic inhibition while αβδ receptors are extra or peri-synaptic and mediate tonic inhibition. Given the different roles of these GABAA receptor isoforms and that GABAA receptors are allosterically regulated by extracell...
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iv Acknowledgement I would like to give my deepest thanks to my mentor, Dr. R. Adron Harris. I have been thinking I have a good fortune to meet him. In the future, I want to be a professor in the academic field. He has been a standard model of academic professor to me. He has been always working on something, patient to me for obtaining data, and critical questions and suggestions during lab-me...
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Zinc is abundantly present in the CNS, and after nerve stimulation is thought to be released in sufficient quantity to modulate the synaptic transmission. Although it is known that this divalent cation inhibits the GABAergic synaptic currents, the underlying mechanisms were not fully elucidated. Here we report that zinc reduced the amplitude, slowed the rise time, and accelerated the decay of m...
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Chick brain mRNA was isolated and injected into Xenopus oocytes. This led to the expression in the surface membrane of functional GABA-activated channels with properties reminiscent of vertebrate GABAA channels. The GABA-induced current was analyzed quantitatively under voltage-clamp conditions. Picrotoxin inhibited this current in a concentration-dependent manner with IC50 = 0.6 microM. The al...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2001
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.2001.00715.x